Heterogeneity in the psychosocial and behavioral responses associated with a diagnosis of suspected Lynch syndrome in women with endometrial cancer

S Jonnagadla; SL Joseland; S Saya; N den Elzen; J Isbister; IM Winship; DD Buchanan

Journal article

Heterogeneity in the psychosocial and behavioral responses associated with a diagnosis of suspected Lynch syndrome in women with endometrial cancer

S Jonnagadla, SL Joseland, S Saya, N den Elzen, J Isbister, IM Winship, DD Buchanan

Hereditary Cancer in Clinical Practice | Published : 2022

DOI: 10.1186/s13053-022-00233-1

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Abstract

Background: A suspected Lynch syndrome (SLS) diagnosis is made when a tumor exhibits DNA mismatch repair deficiency but cannot be definitively assigned to an inherited or non-inherited etiology. This diagnosis poses challenges for healthcare professionals, patients, and their families in managing future cancer risks and clinical care. Methods: This qualitative study aimed to explore the psychosocial and behavioral responses of endometrial cancer (EC) patients receiving a SLS diagnosis (EC-SLS). Semi-structured telephone interviews were conducted with 15 EC-SLS women, transcribed, and thematically analyzed. Results: Most who interpreted their result as negative for Lynch syndrome (LS) believe..

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University of Melbourne Researchers

Sibel Saya Author

Ingrid Winship Author

Daniel Buchanan Author

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Awarded by University of Melbourne

Funding Acknowledgements

This study was supported by a Project Grant from the National Health Medical Research Council (NHMRC) (GNT1125269, PI Buchanan) and the Victorian Government's Operational Infrastructure Support Program. DDB is supported by an NHMRC R.D. Wright Career Development Fellowship (GNT1125268), NHMRC Investigator Grant (GNT1194896) and funding from the University of Melbourne Research at Melbourne Accelerator Program (R@MAP).